Transfusion et maladies du globule rouge
Our team, created in January 2015, is composed of 3 former entities: Etablissement Français du Sang (EFS), Inserm and UPEC. Our 3 entities are involved in red blood cell (RBC) disease pathophysiology and treatment, with a specific focus on sickle cell disease (SCD) and thalassemia. All 3 entities already worked with the referral center of genetic disease of RBC in the H. Mondor Hospital
The former entities are:
– The EFS team directed by Pr F. Pirenne (team leader of the Eq2), which has developed, since 2008 in the H.Mondor Hospital, research projects on transfusion risks in SCD patients and antibody mediated hemolysis in autoimmune haemolytic anemia.
– The Inserm team (ex Inserm U779) specialized in protein polymerisation, blood substitutes and rare RBC diseases. The projects of this team have historically been centred on the RBC, with much of the experimental work at the protein level. The themes include hemoglobin (Hb)-based blood substitutes, the Alpha-Hemoglobin Stabilizing Protein (AHSP), chaperone of alpha chains, and neuroglobin (Ngb).
– The UPEC team specialized in RBC genetic and physiopathology SCD.
The new projects of our group combine the expertise of all members with a specific focus on :
– mechanism of allo immunization against red blood cells
– pathophysiology of post-transfusion hemolysis in sickle cell disease
– role of dense red blood cells in the pathophysiology of sickle cell disease
– study of the free pool alpha in thalassemia and other red blood cell disease
Epidemiological, transversal and fundamental studies are developed on thesis themes.
Our team is a member of the Laboratoire d’Excellence du Globule Rouge, GR-Ex (http://www.labex-grex.com)
Publications récentes
Pirenne F and Yazdanbakhsh K. How I safely transfuse patients with sickle-cell disease and manage delayed hemolytic transfusion reactions
Blood 2018 131:2773-2781Rakotoson MG, Di Liberto G, Audureau E, Habibi A, Fauroux C, Khorgami S, Hulin A, Loric S, Noizat-Pirenne F, Galacteros F, Bartolucci P. Biological parameters predictive of percent dense red blood cell decrease under hydroxyurea.
Orphanet J Rare Dis. 2015 May 9;10(1):57.Noizat-Pirenne F, Habibi A, Mekontso-Dessap A, Razazi K, Chadebech P, Mahevas M, Vingert B, Bierling P, Galactéros F, Bartolucci P, Michel M. The use of rituximab to prevent severe delayed haemolytic transfusion reaction in immunized patients with sickle cell disease.
Vox Sang. 2015 Apr;108(3):262-7.Vingert B, Tamagne M, Habibi A, Pakdaman S, Ripa J, Elayeb R, Galacteros F, Bierling P, Ansart-Pirenne H, Bartolucci P, Noizat-Pirenne F. Phenotypic differences of CD4+ T cells in response to red blood cell immunization in transfused sickle cell disease patients.
Eur J Immunol. 2015 Jun;45(6):1868-1879.Burin des Roziers N, Chadebech P, Bodivit G, Guinchard E, Bruneel A, Dupré T, Chevret L, Jugie M, Gallon P, Bierling P, Noizat-Pirenne F. Red blood cell Thomsen-Friedenreich antigen expression and galectin-3 plasma concentrations in Streptococcus pneumoniae-associated hemolytic uremic syndrome and hemolytic anemia.
Transfusion. 2014 Dec 30. doi: 10.1111/trf.12981.Domingues-Hamdi E, Vasseur C, Fournier JB, Marden MC, Wajcman H, Baudin-Creuza V. Role of α-globin H helix in the building of tetrameric human hemoglobin: interaction with α-hemoglobin stabilizing protein (AHSP) and heme molecule.
PLoS One. 2014 Nov 4;9(11):e111395.Arlet JB, Ribeil JA, Guillem F, Negre O, Hazoume A, Marcion G, Beuzard Y, Dussiot M, Moura IC, Demarest S, de Beauchêne IC, Belaid-Choucair Z, Sevin M, Maciel TT, Auclair C, Leboulch P, Chretien S, Tchertanov L, Baudin-Creuza V, Seigneuric R, Fontenay M, Garrido C, Hermine O, Courtois G. HSP70 sequestration by free α-globin promotes ineffective erythropoiesis in β-thalassaemia.
Nature. 2014 Oct 9;514(7521):242-6.Silvy M, Tournamille C, Babinet J, Pakdaman S, Cohen S, Chiaroni J, Galactéros F, Bierling P, Bailly P, Noizat-Pirenne F. Red blood cell immunization in sickle cell disease: evidence of a large responder group and a low rate of anti-Rh linked to partial Rh phenotype.
Haematologica. 2014 Jul;99(7):e115-7.Mellerio C, Farhat WH, Calvet D, Oppenheim C, Lefaucheur JP, Bartolucci P. Cerebral reorganization of language and motor control secondary to chronic hemispheric vasculopathy in a patient with homozygous sickle-cell disease.
Am J Hematol. 2014 Jun;89(6):662-3.Vingert B, Tamagne M, Desmarets M, Pakdaman S, Elayeb R, Habibi A, Bernaudin F, Galacteros F, Bierling P, Noizat-Pirenne F, Cohen JL. Partial dysfunction of Treg activation in sickle cell disease.
Am J Hematol. 2014 Mar;89(3):261-6.
Documentation
L'équipe
Composition
- Responsable de l'équipe : France Pirenne
- Chercheur : Véronique Baudin-Creuza, Philippe Chadebech, Laurent Kiger, Kim-Anh Nguyen-Peyre, Christophe Tournamille, Benoit Vingert
- Enseignant-Chercheur : Pablo Bartolucci, Aline Floc'h, Frédéric Galacteros, Mehdi Khellaf, Matthieu Mahevas, France Pirenne, Serge Pissard, Corinne Pondarre
- Praticien hospitalier : Anoosha Habibi, Suella Martino, Stéphane Moutereau
- Post doctorant : Pascal Chappert, Deborah Neyrinck
- Doctorant : Nassima Djouder, Nicolas Hebert, Christian Kassasseya, Mehdi Khelfa, Gabriela Luszczewska, Lamisse Mansour-Hendili
- Ingénieur : Emmanuel Adu, Imane Azzaoui, Gwellaouen Bodivit, Elisa Domingues-Hamdi, Steeve Lowenski, Sadaf Pakdaman, Marie Tamagne, Corinne Vasseur
- Technicien : Aurélie Barrault, Alicia Jouard, Alexis Vandenberghe
- Stagiaire : Nour Belkeziz, Lylia Berradhia, Saskia Eckert, Morgane Fournier, Roxane Kponou-Johnson, Romain Rinck
Adresse
IMRB – Inserm U955
Transfusion et maladies du globule rouge (Equipe 2)
Unité d’Ingénierie et de Thérapie Cellulaire Ile-de-France
Etablissement Français du Sang
5, rue Gustave Eiffel
94017 Créteil Cédex
Contact
Tél. : 01 49 81 37 71
Plan d'accès
Actualités du département
Larissa Lipskaïa, Emmanuelle Born, Serge Adnot de l’équipe “Sénescence, métabolisme et maladies cardiovasculaires” de Geneviève Derumeaux, en collaboration avec des équipes du CEA de Saclay, de l’Institut Curie, du Centre de Rechercher en Cancérologie de Lyon, et de l’Institut Pasteur de Lille, viennent de publier un article paru dans la revue American Journal of Respiratory […]
En savoir +Théoricien et spécialiste de la modélisation, Marcel Filoche, DR CNRS au sein de l’équipe de Bruno Louis, vient de recevoir le Prix Mme Claude Berthault décerné par l’Académie des sciences. Ce prix récompense en particulier ses travaux sur la localisation des ondes et la découverte du «paysage de localisation». Les ondes, qu’elles soient […]
En savoir +La dystrophie musculaire de Duchenne est associée à une détérioration progressive de la fonction du ventricule gauche. Le modèle canin de la dystrophie musculaire du golden retriever (GRMD) récapitule la pathologie et les manifestations cliniques de la dystrophie musculaire de Duchenne. Il est important de noter qu’ils développent un dysfonctionnement progressif du ventricule gauche dès […]
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