Transfusion et maladies du globule rouge
Our team, created in January 2015, is composed of 3 former entities: Etablissement Français du Sang (EFS), Inserm and UPEC. Our 3 entities are involved in red blood cell (RBC) disease pathophysiology and treatment, with a specific focus on sickle cell disease (SCD) and thalassemia. All 3 entities already worked with the referral center of genetic disease of RBC in the H. Mondor Hospital
The former entities are:
– The EFS team directed by Pr F. Pirenne (team leader of the Eq2), which has developed, since 2008 in the H.Mondor Hospital, research projects on transfusion risks in SCD patients and antibody mediated hemolysis in autoimmune haemolytic anemia.
– The Inserm team (ex Inserm U779) specialized in protein polymerisation, blood substitutes and rare RBC diseases. The projects of this team have historically been centred on the RBC, with much of the experimental work at the protein level. The themes include hemoglobin (Hb)-based blood substitutes, the Alpha-Hemoglobin Stabilizing Protein (AHSP), chaperone of alpha chains, and neuroglobin (Ngb).
– The UPEC team specialized in RBC genetic and physiopathology SCD.
The new projects of our group combine the expertise of all members with a specific focus on :
– mechanism of allo immunization against red blood cells
– pathophysiology of post-transfusion hemolysis in sickle cell disease
– role of dense red blood cells in the pathophysiology of sickle cell disease
– study of the free pool alpha in thalassemia and other red blood cell disease
Epidemiological, transversal and fundamental studies are developed on thesis themes.
Our team is a member of the Laboratoire d’Excellence du Globule Rouge, GR-Ex (http://www.labex-grex.com)
Publications récentes
Pirenne F and Yazdanbakhsh K. How I safely transfuse patients with sickle-cell disease and manage delayed hemolytic transfusion reactions
Blood 2018 131:2773-2781Rakotoson MG, Di Liberto G, Audureau E, Habibi A, Fauroux C, Khorgami S, Hulin A, Loric S, Noizat-Pirenne F, Galacteros F, Bartolucci P. Biological parameters predictive of percent dense red blood cell decrease under hydroxyurea.
Orphanet J Rare Dis. 2015 May 9;10(1):57.Noizat-Pirenne F, Habibi A, Mekontso-Dessap A, Razazi K, Chadebech P, Mahevas M, Vingert B, Bierling P, Galactéros F, Bartolucci P, Michel M. The use of rituximab to prevent severe delayed haemolytic transfusion reaction in immunized patients with sickle cell disease.
Vox Sang. 2015 Apr;108(3):262-7.Vingert B, Tamagne M, Habibi A, Pakdaman S, Ripa J, Elayeb R, Galacteros F, Bierling P, Ansart-Pirenne H, Bartolucci P, Noizat-Pirenne F. Phenotypic differences of CD4+ T cells in response to red blood cell immunization in transfused sickle cell disease patients.
Eur J Immunol. 2015 Jun;45(6):1868-1879.Burin des Roziers N, Chadebech P, Bodivit G, Guinchard E, Bruneel A, Dupré T, Chevret L, Jugie M, Gallon P, Bierling P, Noizat-Pirenne F. Red blood cell Thomsen-Friedenreich antigen expression and galectin-3 plasma concentrations in Streptococcus pneumoniae-associated hemolytic uremic syndrome and hemolytic anemia.
Transfusion. 2014 Dec 30. doi: 10.1111/trf.12981.Domingues-Hamdi E, Vasseur C, Fournier JB, Marden MC, Wajcman H, Baudin-Creuza V. Role of α-globin H helix in the building of tetrameric human hemoglobin: interaction with α-hemoglobin stabilizing protein (AHSP) and heme molecule.
PLoS One. 2014 Nov 4;9(11):e111395.Arlet JB, Ribeil JA, Guillem F, Negre O, Hazoume A, Marcion G, Beuzard Y, Dussiot M, Moura IC, Demarest S, de Beauchêne IC, Belaid-Choucair Z, Sevin M, Maciel TT, Auclair C, Leboulch P, Chretien S, Tchertanov L, Baudin-Creuza V, Seigneuric R, Fontenay M, Garrido C, Hermine O, Courtois G. HSP70 sequestration by free α-globin promotes ineffective erythropoiesis in β-thalassaemia.
Nature. 2014 Oct 9;514(7521):242-6.Silvy M, Tournamille C, Babinet J, Pakdaman S, Cohen S, Chiaroni J, Galactéros F, Bierling P, Bailly P, Noizat-Pirenne F. Red blood cell immunization in sickle cell disease: evidence of a large responder group and a low rate of anti-Rh linked to partial Rh phenotype.
Haematologica. 2014 Jul;99(7):e115-7.Mellerio C, Farhat WH, Calvet D, Oppenheim C, Lefaucheur JP, Bartolucci P. Cerebral reorganization of language and motor control secondary to chronic hemispheric vasculopathy in a patient with homozygous sickle-cell disease.
Am J Hematol. 2014 Jun;89(6):662-3.Vingert B, Tamagne M, Desmarets M, Pakdaman S, Elayeb R, Habibi A, Bernaudin F, Galacteros F, Bierling P, Noizat-Pirenne F, Cohen JL. Partial dysfunction of Treg activation in sickle cell disease.
Am J Hematol. 2014 Mar;89(3):261-6.
Documentation
L'équipe
Composition
- Responsable : France Pirenne
- Chercheur : Benoit Vingert, Christophe Tournamille, Imane Azzaoui, Laura Bencheikh, Laurent Kiger, Philippe Chadebech, Véronique Baudin-Creuza
- Enseignant-Chercheur : Corinne Pondarre, France Pirenne, Frédéric Galacteros, Matthieu Mahevas, Pablo Bartolucci, Philippe Bierling, Serge Pissard
- Praticien hospitalier : Anoosha Habibi, Mehdi Khellaf
- Post doctorant : Kim-Anh Nguyen-Peyre
- Doctorant : Aline Floc'h, Christian Kassasseya, Geneviève Marcoux, Lamisse Mansour-Hendili, Mehdi Khelfa, Nassima Djouder, Nicolas Hebert
- Ingénieur : Corinne Vasseur, Elisa Domingues-Hamdi, Gwellaouen Bodivit, Marie Tamagne, Sadaf Pakdaman
- Technicien : Alexis Vandenberghe, Alicia Jouard, Aurélie Barrault
- Stagiaire : Romain Rinck, Roxane Kponou-Johnson
Adresse
IMRB – Inserm U955
Transfusion et maladies du globule rouge (Equipe 2)
Unité d’Ingénierie et de Thérapie Cellulaire Ile-de-France
Etablissement Français du Sang
5, rue Gustave Eiffel
94017 Créteil Cédex
Contact
Tél. : 01 49 81 37 71
Plan d'accès
Actualités du département
M. Panel, D. Morin, B. Ghaleh (équipe 3), I. Ruiz, H. Ahmed-Belkacem, J-M. Pawlotsky (équipe 18) L’ischémie hépatique est une complication de la chirurgie hépatique qui implique un dysfonctionnement mitochondrial résultant de l’ouverture des pores de transition de perméabilité mitochondriale (mPTP). La cyclophiline D (PPIF ou CypD) est une peptidyl-prolyl cis-trans isomérase qui régule […]
En savoir +Marielle Bréau, post-doctorante au centre de recherche en cancérologie de Marseille, a reçu le 5 novembre dernier le prix de thèse de l’Université Paris Est pour l’Ecole Doctorale Sciences de la vie et de la Santé (SVS). Ce prix récompense ses travaux réalisés pendant son doctorat à l’IMRB sur « Sénescence cellulaire et physiopathologie […]
En savoir +46 000 personnes sont victimes d’un arrêt cardiaque chaque année en France. Des chercheurs de l’EnvA, de l’Université Paris Est Créteil, de l’Inserm et de l’Institut Mondor de Recherche Biomédicale dont le professeur Renaud Tissier (équipe Bijan Ghaleh), et également le professeur Philippe Micheau de l’Université de Sherbrooke au Canada, proposent une nouvelle approche pour […]
En savoir +