Molecular bases of cigarette smoke-induced COPD

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Maylis Dagouassat Group leader, MCF Maylis Dagouassat

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Selected publications

Baskara I, Kerbrat S, Dagouassat M, Nguyen HQ, Guillot-Delost M, Surenaud M , Baillou C, Lemoine FM, Morin D, Boczkowski J, Le Gouvello S. Cigarette smoking induces human CCR6+Th17 lymphocytes senescence and VEGF-A secretion.

Sci Rep. 2020 Apr 16;10(1):6488. doi: 10.1038/s41598-020-63613-4.

Even B, Fayad-Kobeissi S, Gagliolo JM, Motterlini R, Boczkowski J, Foresti R, Dagouassat M. Heme oxygenase-1 induction attenuates senescence in chronic obstructive pulmonary disease lung fibroblasts by protecting against mitochondria dysfunction.

Aging Cell 2018; 17:e12837 - DOI: 10.1111/acel.12837.

Schlemmer F, Boyer L, Soumagne T, Ridoux A, Chouaid C, Maitre B, Lanone S, Adnot S, Audureau E, Boczkowski J. Beclin1 circulating levels and accelerated aging markers in COPD comment.

Cell Death Dis 2018; 9.

Figeac F, Dagouassat M, Mahrouf-Yorgov M, Le Gouvello S, Trebeau C, Sayed A, Stern JB, Validire P, Dubois-Rande JL, Boczkowski J, et al. Lung fibroblasts share mesenchymal stem cell features which are altered in chronic obstructive pulmonary disease via the overactivation of the Hedgehog signaling pathway.

PLoS One [Internet] 2015; 10:e0121579.

Boyer L, Chouaid C, Bastuji-Garin S, Marcos E, Margarit L, Le Corvoisier P, Vervoitte L, Hamidou L, Frih L, Audureau E, et al. Aging-related systemic manifestations in COPD patients and cigarette smokers.

PLoS One 2015; 10:e0121539.

Dagouassat M, Gagliolo JM, Chrusciel S, Bourin MC, Duprez C, Caramelle P, Boyer L, Hue S, Stern JB, Validire P, Longrois D, Norel X, Dubois-Randé JL, Le Gouvello S, Adnot S, Boczkowski J. The cyclooxygenase-2-prostaglandin E2 pathway maintains senescence of chronic obstructive pulmonary disease fibroblasts.

J. Am J Respir Crit Care Med. 2013 Apr 1;187(7):703-14