Transfusion and Pathologies of the Red Blood Cell
Our team, created in January 2015, is composed of 3 former entities: Etablissement Français du Sang (EFS), Inserm and UPEC. Our 3 entities are involved in red blood cell (RBC) disease pathophysiology and treatment, with a specific focus on sickle cell disease (SCD) and thalassemia. All 3 entities already worked with the referral center of genetic disease of RBC in the H. Mondor Hospital
The former entities are:
– The EFS team directed by Pr F. Pirenne (team leader of the Eq2), which has developed, since 2008 in the H.Mondor Hospital, research projects on transfusion risks in SCD patients and antibody mediated hemolysis in autoimmune haemolytic anemia.
– The Inserm team (ex Inserm U779) specialized in protein polymerisation, blood substitutes and rare RBC diseases. The projects of this team have historically been centred on the RBC, with much of the experimental work at the protein level. The themes include hemoglobin (Hb)-based blood substitutes, the Alpha-Hemoglobin Stabilizing Protein (AHSP), chaperone of alpha chains, and neuroglobin (Ngb).
– The UPEC team specialized in RBC genetic and physiopathology SCD.
The new projects of our group combine the expertise of all members with a specific focus on :
– mechanism of allo immunization against red blood cells
– pathophysiology of post-transfusion hemolysis in sickle cell disease
– role of dense red blood cells in the pathophysiology of sickle cell disease
– study of the free pool alpha in thalassemia and other red blood cell disease
Epidemiological, transversal and fundamental studies are developed on thesis themes.
Our team is a member of the Laboratoire d’Excellence du Globule Rouge, GR-Ex (http://www.labex-grex.com)
Selected publications
Pirenne F and Yazdanbakhsh K. How I safely transfuse patients with sickle-cell disease and manage delayed hemolytic transfusion reactions
Blood 2018 131:2773-2781Rakotoson MG, Di Liberto G, Audureau E, Habibi A, Fauroux C, Khorgami S, Hulin A, Loric S, Noizat-Pirenne F, Galacteros F, Bartolucci P. Biological parameters predictive of percent dense red blood cell decrease under hydroxyurea.
pubmed/25956133Noizat-Pirenne F, Habibi A, Mekontso-Dessap A, Razazi K, Chadebech P, Mahevas M, Vingert B, Bierling P, Galactéros F, Bartolucci P, Michel M. The use of rituximab to prevent severe delayed haemolytic transfusion reaction in immunized patients with sickle cell disease.
pubmed/25523469Vingert B, Tamagne M, Habibi A, Pakdaman S, Ripa J, Elayeb R, Galacteros F, Bierling P, Ansart-Pirenne H, Bartolucci P, Noizat-Pirenne F. Phenotypic differences of CD4+ T cells in response to red blood cell immunization in transfused sickle cell disease patients.
pubmed/25763868Burin des Roziers N, Chadebech P, Bodivit G, Guinchard E, Bruneel A, Dupré T, Chevret L, Jugie M, Gallon P, Bierling P, Noizat-Pirenne F. Red blood cell Thomsen-Friedenreich antigen expression and galectin-3 plasma concentrations in Streptococcus pneumoniae-associated hemolytic uremic syndrome and hemolytic anemia.
pubmed/25556575Domingues-Hamdi E, Vasseur C, Fournier JB, Marden MC, Wajcman H, Baudin-Creuza V. Role of α-globin H helix in the building of tetrameric human hemoglobin: interaction with α-hemoglobin stabilizing protein (AHSP) and heme molecule.
pubmed/25369055Arlet JB, Ribeil JA, Guillem F, Negre O, Hazoume A, Marcion G, Beuzard Y, Dussiot M, Moura IC, Demarest S, de Beauchêne IC, Belaid-Choucair Z, Sevin M, Maciel TT, Auclair C, Leboulch P, Chretien S, Tchertanov L, Baudin-Creuza V, Seigneuric R, Fontenay M, Garrido C, Hermine O, Courtois G. HSP70 sequestration by free α-globin promotes ineffective erythropoiesis in β-thalassaemia.
pubmed/25156257Silvy M, Tournamille C, Babinet J, Pakdaman S, Cohen S, Chiaroni J, Galactéros F, Bierling P, Bailly P, Noizat-Pirenne F. Red blood cell immunization in sickle cell disease: evidence of a large responder group and a low rate of anti-Rh linked to partial Rh phenotype.
pubmed/24727821Mellerio C, Farhat WH, Calvet D, Oppenheim C, Lefaucheur JP, Bartolucci P. Cerebral reorganization of language and motor control secondary to chronic hemispheric vasculopathy in a patient with homozygous sickle-cell disease.
pubmed/24668836Vingert B, Tamagne M, Desmarets M, Pakdaman S, Elayeb R, Habibi A, Bernaudin F, Galacteros F, Bierling P, Noizat-Pirenne F, Cohen JL. Partial dysfunction of Treg activation in sickle cell disease.
pubmed/24779034
Documentation
The team
Composition
- Responsable : France Pirenne
- Chercheur : Véronique Baudin-Creuza, Philippe Chadebech, Laurent Kiger, Kim-Anh Nguyen-Peyre, Christophe Tournamille, Benoit Vingert
- Enseignant-Chercheur : Pablo Bartolucci, Aline Floc'h, Frédéric Galacteros, Mehdi Khellaf, Matthieu Mahevas, France Pirenne, Serge Pissard, Corinne Pondarre
- Praticien hospitalier : Anoosha Habibi, Stéphane Moutereau
- Post doctorant : Pascal Chappert, Deborah Neyrinck, Meghan Perkins
- Doctorant : Nassima Djouder, Nicolas Hebert, Christian Kassasseya, Mehdi Khelfa, Gabriela Luszczewska, Lamisse Mansour-Hendili
- Ingénieur : Emmanuel Adu, Imane Azzaoui, Gwellaouen Bodivit, Elisa Domingues-Hamdi, Sadaf Pakdaman, Marie Tamagne, Corinne Vasseur
- Technicien : Aurélie Barrault, Alicia Jouard, Alexis Vandenberghe
- Stagiaire : Roxane Kponou-Johnson, Romain Rinck
Address
IMRB – Inserm U955
Transfusion and pathologies of the red blood cell (Team 2)
Unité d’Ingénierie et de Thérapie Cellulaire Ile-de-France
Etablissement Français du Sang
5, rue Gustave Eiffel
94017 Créteil Cédex
France
Administrative assistant – Contact
Tél. : +33-1 49 81 37 71
Access map
Department news
Ciliary dyskinesia are a group of heterogeneous diseases characterized by an alteration of the respiratory ciliary beating that may induce a degradation of the mucociliary clearance which is the first line of defense of the respiratory system..
Read moreThe molecular cause of sickle cell disease is the polymerization of mutant hemoglobin S during deoxygenation, which is the cause of the multiple attacks of the disease. The amount of fibres in equilibrium and the kinetics of fibre formation both depend on the concentration of haemoglobin S and the partial pressure of oxygen. Pablo […]
Read more