Pharmacology and Technologies for Cardiovascular Diseases (PROTECT)

Contacts

Head Bijan Ghaleh-Marzban

Tél.: +33-(0)1 43 96 73 85
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PROTECT team researches and develops pharmacological strategies and technologies to reduce the consequences of cardiovascular events such as myocardial infarction, heart failure or cardiac arrest. This research is based on an integrated approach that evolves from cellular models to clinical evaluations and in-depth preclinical studies. This translational approach has led to several clinical trials and the transfer of innovations to the industrial sector.

Objectives of the team

1- research therapeutic approaches to limit the consequences of a cardiac arrest. In particular, we are studying an innovative hypothermia strategy using total liquid ventilation of the lungs during shock following resuscitation;

2- Studying molecules likely to reduce vascular permeability during myocardial infarction or heart failure. In particular, we are evaluating the modulation of myocardial oedema and coronary microcirculation by angiopoietin-like derivatives 4 ;

3- study the heme oxygenase and carbon monoxide pathway in myocardial ischemia, with a focus on inflammatory mechanisms and cellular bioenergetics.

4- to search for new anti-ischemic molecules by targeting the mitochondrial toxicity of cholesterol. The role of the ligands of its translocation protein (TSPO) is particularly evaluated.

The team’s areas of research relate to areas of high societal impact since ischemic cardiovascular disease is one of the leading causes of mortality in humans worldwide. This also corresponds to an important issue for the health of pets.

The team includes scientists, pharmacists, veterinarians and physicians, providing a wide range of expertise. This allows us to consider research from the “fundamental” to the transfer to the human or veterinary clinic.

Moreover, the development of original pharmacological strategies or medical devices is fully in line with a valorisation approach. It is therefore research that has a strong potential for transfer and economic impact.

The team is organized into three groups led by Bijan Ghaleh, Roberto Motterlini and Renaud Tissier.

The laboratories are located at the Faculty of Medicine of Créteil and at the National Veterinary School of Alfort.

Selected publications