Pharmacological strategies and experimental therapeutics for myocardial ischemia and heart failure
The team investigates the pathophysiology and pharmacology of coronary disease and cardiac failure. Our facilities are closely linked to Henri Mondor hospital (PHYDES department “Ageing-Thorax, Vessel, Blood” DHU) and involve two integrated and nearly located labs in the National Veterinary School of Maisons-Alfort (ENVA) and Creteil Medical School (Université Paris Est Créteil). For 2015-2019, the objectives are to further investigate the physiopathological mechanisms leading to left ventricular (LV) dysfunction and to develop original and innovative pharmacological strategies to prevent or reduce LV dysfunctions.
Our goal is to establish proofs of concepts
1) for new pharmacological/technological developments and
2) to promote translational clinical research.
Our first aim is to protect the heart and to reduce infarct size by targeting the mitochondrial cholesterol translocation with TSPO ligands or by using new molecules targeting the mitochondrial cyclophilin D. Protection of the coronary vasculature with angiopoietin-like 4 will be also a main topic of the team as well as impact of comorbidities such as obesity.
Our second aim is to evaluate the consequences of cardiac arrest by deciphering the benefits afforded by hypothermia with total liquid ventilation and developing specific liquid ventilators for clinical use.
Our third aim is to study LV dysfunction and its calcium-related mechanism in an original hypertensive pig model that develops diastolic dysfunction and ultimately heart failure with preserved ejection fraction.
All these objectives also include clinical translation with ongoing and new clinical trials. In addition, within ENVA, our programs will be extended to animals with spontaneous and/or genetic diseases (e.g., Golden Retriever Muscular Dystrophy dogs mimicking human Duchenne myopathy).
Finally, the team will remain highly involved in student training (doctoral school “Sciences de la Vie et de la Santé”).
Selected publications
Kohlhauer M1, Lidouren F, Remy-Jouet I, Mongardon N, Adam C, Bruneval P, Hocini H, Levy Y, Blengio F, Carli P, Vivien B, Ricard JD, Micheau P, Walti H, Nadeau M, Robert R, Richard V, Mulder P, Maresca D, Demené C, Pernot M, Tanter M, Ghaleh B, Berdeaux A, Tissier R. Hypothermic Total Liquid Ventilation Is Highly Protective Through Cerebral Hemodynamic Preservation and Sepsis-Like Mitigation After Asphyxial Cardiac Arrest.
Crit Care Med. 2015 Jun 23. [Epub ahead of print]Su JB, Cazorla O, Blot S, Blanchard-Gutton N, Ait Mou Y, Barthelemy I, Sambin L, Sampedrano CC, Gouni V, Unterfinger Y, Aguilar P, Thibaud JL, Bize A, Pouchelon JL, Dabire H, Ghaleh B, Berdeaux A, Chetboul V, Lacampagne A, Hittinger L. Bradykinin restores left ventricular function, sarcomeric protein phosphorylation and e/nNOs levels in dogs with Duchenne muscular dystrophy cardiomyopathy.
Cardiovasc Res. 2012; 95:86-96. (IF 5.9)Rienzo M, Bizé A, Pongas D, Michineau S, Melka J, Chan HL, Sambin L, Su JB, Dubois-Randé JL, Hittinger L, Berdeaux A, Ghaleh B. Impaired left ventricular function in the presence of preserved ejection in chronic hypertensive conscious pigs.
Basic Res Cardiol. 2012; 107: 298. (IF 5.9)Galaup A, Gomez E, Souktani R, Durand M, Cazes A, Monnot C, Teillon J, Le Jan S, Bouleti C, Briois G, Philippe J, Pons S, Martin V, Assaly R, Bonnin P, Ratajczak P, Janin A, Thurston G, Valenzuela DM, Murphy AJ, Yancopoulos GD, Tissier R, Berdeaux A, Ghaleh B, Germain S. Protection against myocardial infarction and no-reflow through preservation of vascular integrity by angiopoietin-like 4.
Circulation. 2012; 125: 140-9. (IF 15.2)Chenoune M, Lidouren F, Adam C, Pons S, Darbera L, Bruneval P, Ghaleh B, Zini R, Dubois-Rande JL, Carli P, Vivien B, Ricard JD, Berdeaux A, Tissier R. Ultrafast and whole-body cooling with total liquid ventilation induces favorable neurological and cardiac outcomes after cardiac arrest in rabbits.
Circulation. 2011; 124: 901-11, 1-7. (IF 15.2).Couvreur N, Tissier R, Pons S, Chetboul V, Gouni V, Bruneval P, Mandet C, Pouchelon JL, Berdeaux A, Ghaleh B. Chronic heart rate reduction with ivabradine improves systolic function of the reperfused heart through a dual mechanism involving a direct mechanical effect and a long-term increase in FKBP12/12.6 expression.
Eur Heart J. 2010; 31: 1529-37. (IF 14.0).The team
Composition
- Chef d'équipe : Bijan Ghaleh-Marzban
- Praticien hospitalier : Pierre-Louis Léger
- Chercheur : Didier Morin, Hubert Dabiré, Jin Bo Su
- Enseignant-Chercheur : Alain Berdeaux, Alexandra D'Anglemont de Tassigny, Bijan Ghaleh-Marzban, Caroline Barau, Claire Pressiat, Emmanuel Teiger, Jean-Luc Dubois-Randé, Leeyah Issop-Merlen, Luc Hittinger, Matthias Kohlhauer, Nicolas Mongardon, Philippe Le Corvoisier, Renaud Tissier, Sandrine Pons, Valérie Chetboul
- Doctorant : Emilie Boissady, Juliette Bréhat, Romain Gallet, Shirin Leick
- Ingénieur : Alain Bizé, Cécile Lecointe, Fanny Lidouren
- Technicien : Lucien Sambin
- Stagiaire : Estelle Faucher, Paul-Matthieu Chiaroni, Quentin De Roux
Address
IMRB – Inserm U955
Cardioprotection and pharmacology of coronary and cardiac failures (Team 3)
Faculty of Medicine at Créteil – 3rd floor
8, rue du Général Sarrail
94010 Créteil
France
Administrative assistant – Contact
Tél. : +33-1 49 81 35 30
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Department news
The British Heart Foundation (BHF) is a UK charity established in 1961 by a group of health professionals to fund additional research into the causes, diagnosis, treatment and prevention of heart and circulatory disease. It is the leading independent funder of cardiovascular research. The BHF Alumni is the free membership program designed to support its […]
Read moreAccording to a recent study coordinated by Pablo Bartolucci of Team 2, with the help of the Department of Public Health and Cardiorespiratory Rehabilitation of CHU Henri Mondor and published in the journal Lancet Haemtology in November 2018, physical exercise would bring definite benefits in the treatment of sickle cell disease. The article appeared in […]
Read moreA recent study conducted by Laura Braud, post-doctoral fellow in the Equipe directed by Roberto Motterlini (Equipe 12, IMRB), reveals that carbon monoxide (CO) improves insulin resistance and glucose metabolism in obese mice. The study appeared in the November issue of JCI Insight (Link: https://insight.jci.org/articles/view/123485). Braud and colleagues showed that oral administration of a compound […]
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