Publication of an article resulting from the collaboration of teams 3 and 18, in the excellent journal Gastroenterology!


M. Panel, D. MOrin, B. Ghaleh (équipe 3), I. Ruiz, H. Ahmed-Belkacem, J-M. Pawlotsky


Hepatic ischemia is a complication of liver surgery that involves mitochondrial dysfunction resulting from the opening of mitochondrial permeability transition pores (mPTP). Cyclophiline D (PPIF or CypD) is a peptidyl-prolyl cis-trans isomerase that regulates the mPTP opening in the inner mitochondrial membrane.


The teams of Bijan Ghaleh and Jean-Michel Pawlotsky, in collaboration with the Centre de Biochimie Structurale de Montpellier, have just published an article in the excellent journal Gastroenterology (IF 2018/19 : 19.233), where we learn that inhibitors of small cyclophiline molecules block the opening of the transition pore from mitochondrial permeability and protect mice from ischemia-reperfusion hepatic damage.


To be read in Gastroenterology of 20/07/2019