Publication of an article resulting from the collaboration of teams 3 and 18, in the excellent journal Gastroenterology!
M. Panel, D. MOrin, B. Ghaleh (équipe 3), I. Ruiz, H. Ahmed-Belkacem, J-M. Pawlotsky
Hepatic ischemia is a complication of liver surgery that involves mitochondrial dysfunction resulting from the opening of mitochondrial permeability transition pores (mPTP). Cyclophiline D (PPIF or CypD) is a peptidyl-prolyl cis-trans isomerase that regulates the mPTP opening in the inner mitochondrial membrane.
The teams of Bijan Ghaleh and Jean-Michel Pawlotsky, in collaboration with the Centre de Biochimie Structurale de Montpellier, have just published an article in the excellent journal Gastroenterology (IF 2018/19 : 19.233), where we learn that inhibitors of small cyclophiline molecules block the opening of the transition pore from mitochondrial permeability and protect mice from ischemia-reperfusion hepatic damage.
To be read in Gastroenterology of 20/07/2019
Incoming seminars
When Chemistry Meets Health – 3rd IMRB/ICMPE Seminar: Anticancer Therapy: Use of a Multivalent Nucleolin Antagonist in Free or Polyplexed Form :
«3rd IMRB/ICMPE Seminar - José COURTY et Jacques PENELLE - De 11h30 à 13h – Webconférence Zoom»
Breaking the Senescence code “S-ENCODE”. Towards therapeutic opportunities :
«Oliver BISCHOF - 12h – Amphi 4 - RDC de la Faculté de Santé»
Séminaire technique BD Rhapsody™: Plateforme Single Cell : Combiner Expression Multigénique et profil immunophénotypique à l’échelle de la Cellule Unique :
«Laurence MONNET - De 15h à 17h – Amphi 5, 4ème étage de la Faculté de Santé de Créteil»
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