Congratulations to Geneviève Derumeaux’s team, team 8, for a very interesting article on visceral adipose tissue, heart aging and osteopontin!
Visceral adipose tissue regulates cardiac aging. Osteopontin (OPN) is a matricellular protein that is upregulated in pathologic cardiac fibrosis and remodeling models. OPN plasma levels also increase with age.
A new study conducted by Daïgo Sawaki within Team 8, reveals that OPN secreted by visceral adipose tissue (VAT) promotes interstitial fibrosis associated with age in the heart. This study was published in Circulation on March 2, 2018, and was the subject of a news item in Nature Reviews Cardiology on March 22.
This study was the result of local collaborations within IMRB (Team 16), national collaborations (IHU ICAN, Inserm Unit 1065 in Nice) and international collaborations with Yokamoma University in Japan.
Tissue damage induces a conserved stress response that initiates quiescent muscle stem cell activation :
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