Carbon monoxide-induced metabolic switch in adipocytes improves insulin resistance in obese mice JCI Insight, November 15, 2018
A recent study conducted by Laura Braud, post-doctoral fellow in the Equipe directed by Roberto Motterlini (Equipe 12, IMRB), reveals that carbon monoxide (CO) improves insulin resistance and glucose metabolism in obese mice. The study appeared in the November issue of JCI Insight (Link: https://insight.jci.org/articles/view/123485).
Braud and colleagues showed that oral administration of a compound that delivers controlled amounts of CO (CORM-401) to mice fed a high-fat diet resulted in a significant reduction in body weight gain and a marked improvement in glucose homeostasis. The study allowed to identify a novel mechanism by which CO accumulates in visceral adipose tissue and uncouples mitochondrial respiration, ultimately leading to a concomitant switch toward glycolysis.
Laura presented the findings of this study at the 10th International Conference on Heme Oxygenase in Seoul (from 29 Oct to 4 Nov 2018) where she received a Young Investigator Award.
The Non-Hemostatic Aspects of Platelets: in an infectious or non-infectious context :
«Fabrice Cognasse - 10h – Salle de réunion UITC, Centre Félix Reyes, 1er étage, 5 rue Gustave Eiffel, 94000 Créteil»
6ème séminaire inter-équipes IMRB : Equipe 2/Equipe 16 :
«6ème séminaire inter-équipes IMRB : Equipe 2/Equipe 16 - 12h – Faculté de Médecine de Créteil»
Axe intestin-cerveau dans l’autisme :
«Alexandru Gaman - 13h30 – Centre de Formation (Pavillon Léonie Chaptal), Pôle de Psychiatrie – Hôpital A. Chenevier – 40, Rue de Mesly – 94000 Créteil »
All incoming seminars
A research and medical care network for psychiatryRead more
Vaccine research institute
An institute to foster the design of vaccines against HIV and hepatitis CRead more