News
April 28 2020
Hepatocellular carcinoma is responsible for one third of cancer deaths worldwide, and most often develops in a context of chronic inflammation. While the immune microenvironment of tumours plays a decisive role in their evolution and is the subject of numerous studies, the role of immunity during the early stages of carcinogenesis remains little studied. In […]
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March 11 2020
Predicting the prognosis of cancers is very important for adapting treatment regimens. A study conducted under the direction of Dr. Julien Calderaro (Pawlotsky Team),
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March 5 2020
Ciliary dyskinesia are a group of heterogeneous diseases characterized by an alteration of the respiratory ciliary beating that may induce a degradation of the mucociliary clearance which is the first line of defense of the respiratory system..
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March 2 2020
Adenosine-to-inosine (A-to-I) RNA editing, mediated by enzymes of the ADAR family, is a well-known contributor of transcriptomic and, to a lesser extent, proteomic diversity.
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February 21 2020
Publication in the January issue of the journal Blood of an article co-authored by members of Nicolas Ortonne’s team in collaboration with teams from Toulouse, among others, describing for the first time the mutational landscape – notably involving activation of the JAK-STAT pathway and disruption of the epigenetic – of a new form of lymphoma, […]
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February 17 2020
Mathieu Panel, ex-PhD student of Bijan Ghaleh-Marzban’s team, recently received the Prix des Sciences du Médicament from the French National Academy of Pharmacy for his thesis work under the supervision of Didier Morin entitled “Study of the effect of new cyclophilin D ligands on the mitochondrial permeability transition pore and their protective effect”. […]
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February 3 2020
We are pleased to announce the establishment of the Scientific Integrity Cell of the IMRB (CIS-IMRB). The main missions of this cell are :
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January 30 2020
Many agents of the IMRB were present on this Tuesday, January 21, 2020 for the greetings of our director Jorge Boczkowski in the Alain Harf room of the Faculty of Health of Créteil. Following the evaluation of our Centre by the HCERES from 13 to 15 March 2019, and whose results were very positive, […]
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December 27 2019
46,000 people suffer cardiac arrest every year in France. Researchers from EnvA, the University of Paris Est Créteil, Inserm and the Mondor Institute for Biomedical Research, including Professor Renaud Tissier (Bijan Ghaleh team), and also Professor Philippe Micheau from the University of Sherbrooke in Canada, are proposing a new approach to better manage them and […]
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November 26 2019
Le Vaccine Research Institute (VRI) et l’ANRS sont heureux d’annoncer avec leurs partenaires Novasep et GTP Technology, la production et la libération du premier lot clinique d’un vaccin anti-VIH pour une première administration chez l’Homme. Le partenariat établi entre le VRI, l’ANRS, Novasep et GTP Technology en septembre 2016 a permis la […]
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November 14 2019
Marielle Bréau, a post-doctoral fellow at the Marseille cancer research centre, received the thesis prize from the University of Paris Est for the Doctoral School of Life and Health Sciences (SVS) on 5 November. This prize rewards his work during his PhD at the IMRB on “Cellular senescence and pathophysiology of chronic lung diseases: […]
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September 19 2019
Under the chairmanship of Sir Malcolm Grant (recently President of the NHS England) and on the proposal of an international jury, the Prime Minister has selected 24 winners of the second wave of calls for projects “University Schools of Research“. Among them, EUR LIVE aims to address the problem of vulnerability by […]
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September 11 2019
M. Panel, D. MOrin, B. Ghaleh (équipe 3), I. Ruiz, H. Ahmed-Belkacem, J-M. Pawlotsky Hepatic ischemia is a complication of liver surgery that involves mitochondrial dysfunction resulting from the opening of mitochondrial permeability transition pores (mPTP). Cyclophiline D (PPIF or CypD) is a peptidyl-prolyl cis-trans isomerase that regulates the mPTP opening in the […]
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August 1 2019
Frédérique Vidal, Minister of Higher Education, Research and Innovation, Emmanuelle Wargon, Secretary of State to the Minister of State, Minister of Ecological and Solidarity Transition, Agnès Pannier-Runacher, Secretary of State to the Minister of the Economy and Finance and Guillaume Boudy, Secretary General for Investment, distinguished 140 winners of the i-Lab and i-Nov Innovation Competitions, […]
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July 3 2019
Cindy Orvain, team 16 of the IMRB, has recently obtained her thesis with success. It is on the cover of the internal magazine Inserm In Vivo* in June 2019. She recounts her journey as part of the 16 team she joined in 2015, where she studies the regulation of effective responses of T cells and […]
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May 24 2019
Autonomic nerve fibres in the tumour microenvironment regulate cancer initiation and dissemination, but how nerves emerge in tumours is currently unknown. Here we show that neural progenitors from the central nervous system that express doublecortin (DCX+) infiltrate prostate tumours and metastases, in which they initiate neurogenesis. In mouse models of prostate cancer, oscillations of […]
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