April 28 2020

Publication in Clinical Cancer Research of a directed study by Dr. J. Calderaro, (J-M. Pawlotsky team) showing that modifications immunity occurs very early in the malignant transformation on cirrhotic liver.

Hepatocellular carcinoma is responsible for one third of cancer deaths worldwide, and most often develops in a context of chronic inflammation. While the immune microenvironment of tumours plays a decisive role in their evolution and is the subject of numerous studies, the role of immunity during the early stages of carcinogenesis remains little studied. In […]

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February 21 2020

New in the description of anaplastic lymphoma on breast implants!

Publication in the January issue of the journal Blood of an article co-authored by members of Nicolas Ortonne’s team in collaboration with teams from Toulouse, among others, describing for the first time the mutational landscape – notably involving activation of the JAK-STAT pathway and disruption of the epigenetic – of a new form of lymphoma, […]

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February 17 2020

Congratulations to Mathieu Panel (ex-PhD student of Bijan Ghaleh’s team), winner of the Drug Science Award!

Mathieu Panel, ex-PhD student of Bijan Ghaleh-Marzban’s team, recently received the Prix des Sciences du Médicament from the French National Academy of Pharmacy for his thesis work under the supervision of Didier Morin entitled “Study of the effect of new cyclophilin D ligands on the mitochondrial permeability transition pore and their protective effect”.     […]

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January 30 2020

Greetings from the Director of the IMRB, Tuesday 21 January 2020

Many agents of the IMRB were present on this Tuesday, January 21, 2020 for the greetings of our director Jorge Boczkowski in the Alain Harf room of the Faculty of Health of Créteil.   Following the evaluation of our Centre by the HCERES from 13 to 15 March 2019, and whose results were very positive, […]

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December 27 2019

Using cold and liquid ventilation to reduce the risk of after-effects following cardiac arrest: Researchers from ENVA, UPEC, Inserm and the Mondor Institute are at the forefront of this new technique.

46,000 people suffer cardiac arrest every year in France. Researchers from EnvA, the University of Paris Est Créteil, Inserm and the Mondor Institute for Biomedical Research, including Professor Renaud Tissier (Bijan Ghaleh team), and also Professor Philippe Micheau from the University of Sherbrooke in Canada, are proposing a new approach to better manage them and […]

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November 26 2019

HIV vaccine clinical batch release: a major milestone for the Vaccine Research Institute’s vaccine development program.

     Le Vaccine Research Institute (VRI) et l’ANRS sont heureux d’annoncer avec leurs partenaires Novasep et GTP Technology, la production et la libération du premier lot clinique d’un vaccin anti-VIH pour une première administration chez l’Homme.   Le partenariat établi entre le VRI, l’ANRS, Novasep et GTP Technology en septembre 2016 a permis la […]

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November 14 2019

Marielle Bréau former doctoral student of Serge Adnot’s team, winner of the Thesis Prize of the University of Paris-Est for the Doctoral School of Life Sciences and Health!

Marielle Bréau, a post-doctoral fellow at the Marseille cancer research centre, received the thesis prize from the University of Paris Est for the Doctoral School of Life and Health Sciences (SVS) on 5 November.   This prize rewards his work during his PhD at the IMRB on “Cellular senescence and pathophysiology of chronic lung diseases: […]

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September 19 2019

EUR LIVE “Trajectories and Vulnerability in Health”, one of UPEC’s University Research Schools projects, has been selected from 81 applications!

      Under the chairmanship of Sir Malcolm Grant (recently President of the NHS England) and on the proposal of an international jury, the Prime Minister has selected 24 winners of the second wave of calls for projects “University Schools of Research“. Among them, EUR LIVE aims to address the problem of vulnerability by […]

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September 11 2019

Publication of an article resulting from the collaboration of teams 3 and 18, in the excellent journal Gastroenterology!

  M. Panel, D. MOrin, B. Ghaleh (équipe 3), I. Ruiz, H. Ahmed-Belkacem, J-M. Pawlotsky   Hepatic ischemia is a complication of liver surgery that involves mitochondrial dysfunction resulting from the opening of mitochondrial permeability transition pores (mPTP). Cyclophiline D (PPIF or CypD) is a peptidyl-prolyl cis-trans isomerase that regulates the mPTP opening in the […]

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August 1 2019

Orixha, a company promoting Team 3 research, is the winner of the 2019 MESR I-LAB competition!

Frédérique Vidal, Minister of Higher Education, Research and Innovation, Emmanuelle Wargon, Secretary of State to the Minister of State, Minister of Ecological and Solidarity Transition, Agnès Pannier-Runacher, Secretary of State to the Minister of the Economy and Finance and Guillaume Boudy, Secretary General for Investment, distinguished 140 winners of the i-Lab and i-Nov Innovation Competitions, […]

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May 24 2019

Virginie Firlej (team 7), co-author with the CEA of Fontenay-aux_Roses, of a publication in the journal Nature of May 15 on neural progenitors of the central nervous system expressing double-cortin (DCX+), infiltrate prostate tumors and metastases, and initiate neurogenesis.

  Autonomic nerve fibres in the tumour microenvironment regulate cancer initiation and dissemination, but how nerves emerge in tumours is currently unknown. Here we show that neural progenitors from the central nervous system that express doublecortin (DCX+) infiltrate prostate tumours and metastases, in which they initiate neurogenesis. In mouse models of prostate cancer, oscillations of […]

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