March 24 2021

Congratulations to Mathieu Panel (ex-doctoral fellow of the Ghaleh team) honored in the Journal of Pharmacology and Experimental Therapeutics of March 2021!

After receiving the Prix des Sciences du Médicament by the French National Academy of Pharmacy in February 2020, Mathieu Panel, a former IMRB doctoral student in Bijan Ghaleh’s team, has just been highlighted as a trainee author in the Journal of Pharmacology and Experimental Therapeutics in the March 2021 issue.   The paper for which […]

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March 11 2021

A study on the nature and significance of the early cellular responses as they occur in vivo after tissue injury, is published in Cell Stem Cell from the Team-Relaix

In multicellular organisms, cells dynamically interact with the microenvironment, which determines their properties and gene-expression profile. Tissue damage, such as injury or experimental cell dissociation, leads to dramatic modifications of the niche, yet the early cellular responses in vivo remain ill-defined. Focusing on two highly regenerative organs, the skeletal muscle and the liver, we identified […]

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March 3 2021

Congratulations to Isaac Ruiz, Jean-Michel Pawlotsky’s team, winner of the Special Jury Prize (University Prize 2020) for his doctoral thesis in Hepatology and Virology

Each year, the Val-de-Marne Department supports research by rewarding the best academic work through the University Prize.   Isaac Ruiz received the Special Jury Prize for his doctoral thesis from the University of Paris-Est Créteil in Hepatology and Virology: Development of new therapeutic approaches in Virology and Hepatology: Small-Molecule Cyclophilin Inhibitors (SMCypI).   Isaac Ruiz […]

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February 15 2021

Congratulations to Philippos Mourikis, Frédéric Relaix’s team! His Calci-Notch project in the framework of the International Call for Research Projects (PRI) 2020, has been selected by Inserm among more than 70 projects submitted

Launched in June 2020, the International Research Project (PRI) call was a great success with more than 70 projects submitted for this first edition.   Only 15 projects have been selected, and that of Philippos Mourikis, DR in Fred Relaix’s team, in collaboration with Dr. Fukada’s team from the University of Osaka in Japan, is […]

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February 5 2021

Publication in Cell of a study led by Matthieu Mahevas of the Pirenne team, in collaboration with several IMRB teams, on the maturation and persistence of the anti-SARS-CoV-2 and COVID-19 immune response.

B memory cells play a fundamental role in the host’s defenses against viruses, but so far their role has been relatively undefined in the context of CoV-2 SARS.   Matthieu Mahévas and several members of the Pirenne team, associated with several teams at the Institute (Bastuji-Garin, Cohen, Lévy and Pawlotsky teams), the Necker Institute for […]

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January 20 2021

Interview with Marcel Filoche, Bruno Louis’ team in the France Culture program “La méthode scientifique” on the benefits of Surfactant Substitution Therapy in patients with severe COVID-19 and who develop an Acute Respiratory Distress Syndrome (ARDS)

In the deepest parts of the pulmonary air shaft, gas exchange between air and blood takes place within about 500 million alveoli (small spherical chambers about 1/4 mm in diameter). The surface of these alveoli, whose developed surface is of the order of 100 m^2 in the adult, is lined with a liquid layer itself […]

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January 13 2021

IMRB’s Relaix team publishes in the journal Cell Metabolism the discovery of a mitochondrial transfer mechanism from platelets activating the repair function of mesenchymal stem cells

Platelets are commonly used in clinical applications. In particular, they are known to stimulate the repair properties of mesenchymal stem cells, these effects being usually attributed to the many growth factors that they release following their activation.   The study headed by Anne-Marie Rodriguez with Jennyfer Levoux, Alexandre Prola and Peggy Lafuste as first co-authors […]

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January 6 2021

A mechanism controlling the efficiency of mitochondrial coupling has been revealed: mechanistic and medical perspectives

In an article available here, published on January 1st in Science Advances, the comparative medical genetics group of the BNMS team reveals an original mechanism by which the content of cardiolipin, a phospholipid present in the inner membrane of mitochondria, controls the coupling efficiency between the oxidation of energy substrates and the phosphorylation of ADP […]

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December 9 2020

Main issues and limitations of the contribution of Artificial Intelligence (AI) for the management of patients with gastrointestinal and hepatic cancers

Artificial Intelligence (AI) can extract complex information from visual data. Histopathological images of cancers indeed contain a very large amount of information that human observers can only partially understand.   Thus, AI allows a thorough analysis of digitized histological slides and offers a wide range of clinically relevant applications, such as the identification of prognostically […]

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November 26 2020

Four UPEC students from the France Pirenne team, honored by the management of the EFS!

The management of the EFS has recently published an article highlighting 4 former UPEC Master 2 students (Marion Pinheiro, Louise Pannetier, Latifa Ben Hassen and Justine Coombs) who did their internship with the France Pirenne team of our Institute.   Supervised by Benoît Vingert and Marie Tamagne, their research work on post-transfusion alloimmunization has resulted […]

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November 19 2020

Publication in The Lancet Oncology of a study led by Christos Chouaid (CHI Créteil – Service de Pneumologie, IMRB-U955 Bastuji-Garin team) on the benefits of a new treatment for patients with recurrent small cell lung cancer

Topotecan is currently the only drug approved in Europe in a second-line setting for the treatment of small cell lung cancer.   This study led by Prof. Christos Chouaid (Department of Pneumology at the CHI de Créteil – IMRB U955, Bastuji-Garin team) aimed to determine whether the carboplatin plus etoposide doublet was superior to Topotecan […]

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September 16 2020

IMI2 CARE Project: VRI-Inserm, coordinator of the European Public-Private Consortium, created to accelerate the development of Covid-19 treatments

The largest European initiative to accelerate the development of therapies for COVID-19 and future coronavirus threats was launched in Brussels on August 18. CARE (Corona Accelerated R&D in Europe) is a €77.7 million European public-private consortium of the Innovative Medicines Initiative (IMI) created to accelerate the development of therapies for Covid-19 and coronaviruses.   Professor […]

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August 3 2020

Ebola survivors show severe immune system abnormalities two years after their disease (Nature Communication of 24/07/2020)

VRI (Vaccine Research Institute)/ INSERM/UPEC (U955, IMRB) in collaboration with several Inserm and IRD teams has just published a study in Nature Communications on 24 July showing that Ebola survivors suffer serious immune system sequelae two years after their disease.   Continuing to wreak havoc in the Democratic Republic of Congo four years after the […]

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July 4 2020

Arrival of a startup in the new EnvA Chauveau building in interaction with Frédéric Relaix’s BNMS team

The École nationale vétérinaire d’Alfort is pleased to welcome within its new research platform, the Auguste Chauveau building, the start-up “Encefa” to develop a promising scientific partnership in terms of innovation and research on neurodegenerative and inflammatory diseases.   The start up “Encefa” integrated, in June, the premises of our platform dedicated to research in […]

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