News
April 25 2022
The Young Researchers’ Symposium mobilizes the French “muco” community around research. The 23rd edition took place this year on February 15, in a mixed format with a “remote” audience and a majority of speakers present at the association’s headquarters. Twenty young researchers (selected by an ad hoc committee from 42 applications received) presented their […]
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April 19 2022
The Omicron variant of SARS-CoV-2 can escape neutralization by vaccine-induced antibodies as well as by antibodies from convalescent plasma. Memory B cells (MBs) represent a protective bulwark against SARS-CoV-2 because they persist after infection and vaccination enhances their affinity. The ability of BMs, generated by mRNA vaccines, to recognize the Omicron variant remains unknown […]
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April 8 2022
Leukemia is a group of several types of blood cancer that affect up to 10,000 people in France each year. One of the proposed treatments is the transplant of hematopoietic stem cells. These cells are produced by the bone marrow and are the source of the various blood cells. Despite the success of this therapeutic […]
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March 1 2022
The COVID-19 pandemic is a reminder of the reality of so-called emerging infectious diseases. These diseases represent in a caricatural way the “One Health” concept of a single health shared by humans and animals in their environment. This concept, which has become obvious in recent years, is the subject of numerous national and international projects. […]
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February 21 2022
Immune gene signatures reflecting the quality and quantity of the intra-tumor immune infiltration are known to predict sensitivity to immunotherapy, but their use in the clinical setting is however challenging, as they require access to molecular biology platforms for the extraction of nucleic acids and their processing/sequencing. They are also highly dependent on sample quality […]
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February 7 2022
The project led by Roberta Foresti, Roberto Motterlini, Sandrine Pons and Bijan Ghaleh, focuses on the release of Danger Associated Molecular Patten (DAMP) during myocardial infarction, in particular heme. The main objective is to demonstrate the role of heme, as DAMP and as a signal for HO-1 activation to modulate inflammation, protect the myocardium […]
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January 31 2022
In the HGB-205 phase I/II clinical trial, four patients with transfusion-dependent beta thalassemia and three patients with sickle cell disease, aged 13 to 21 years, were treated with lentiviral gene therapy. They were followed for a median of 4.5 years. The patients with beta thalassemia all became “transfusion independent” within the first month […]
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January 24 2022
Promoted by the CHIC of Créteil with the support of the CRC of the CHIC, the results of the SEPREVEN* study were published on January 21, 2022 in the journal The Lancet. This study is the result of a collaborative effort: it was coordinated by Dr. Laurence Caeymaex, head of the neonatal intensive care […]
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January 5 2022
In a work led by two members of Sylvie Bastuji-Garin’s CEpiA team (Etienne Audureau and Thibaud Damy) as part of Louis Bonnefous‘ thesis, the authors used innovative machine learning and visualization approaches to identify typical clinical profiles in a large population of suspected cardiac amyloidosis patients. Clustering analysis identified 7 clinical profiles with varying […]
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December 18 2021
Duchenne muscular dystrophy is associated with progressive deterioration of left ventricular function. The golden retriever canine model of muscular dystrophy (GRMD) recapitulates the pathology and clinical manifestations of Duchenne muscular dystrophy. It is important to note that they develop progressive left ventricular dysfunction at an early age. In an article (with an editorial) published […]
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December 13 2021
Mixed hepatocholangiocarcinoma (cHCC-CCA) tumors are rare primary liver cancers associated with a very poor prognosis. They are resistant to all conventional cancer therapies and are characterized by the presence of a dual phenotype of both hepatocyte and biliary tumors. In a study conducted by Cong Trung Nguyen, Stefano Caruso and Pascale Maillé under the supervision […]
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December 7 2021
The Grand Prize recognizes the innovative nature of his work, particularly on bipolar disorders, schizophrenia and autism spectrum disorders. Just forty years ago, Marion Leboyer encountered psychiatry “by chance,” she admits. When choosing internship positions, I didn’t get the one for neuro-pediatric resuscitation, and I took what seemed to me to be the furthest from […]
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December 2 2021
Theorist and specialist in modeling, Marcel Filoche, DR CNRS in the team of Bruno Louis, has just received the Prix Mme Claude Berthault awarded by the Academy of Sciences. This prize is awarded in particular for his work on wave localization and the discovery of the “localization landscape”. The waves, whether they are […]
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November 26 2021
This prize, worth €105,600, comes from a donation by Sylvie Pomaret. Created in memory of his mother, it is intended to support research on rare diseases and finances a 3-year doctoral contract. Yannis Djeffal is pursuing a double degree in Medicine and Science. He is doing his doctoral work in science under the joint supervision […]
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October 1 2021
Pauline Favre is a neuropsychologist, recently recruited at INSERM as a CRCN researcher in Marion Leboyer’s team “Neuropsychiatrie Translationnelle”. She did her PhD in Psychology, Cognitive Sciences and Neurocognition at the University of Grenoble (LPNC – CNRS) on the brain correlates of bipolar disorder and the contribution of psychoeducation in the treatment of this […]
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September 28 2021
Teams from Henri-Mondor Hospital AP-HP and Université Paris-Est Créteil, Inserm, CNRS, Université de Paris, Institut Necker-Enfants malades, and Institut Pasteur have conducted research on the ability of the immune memory generated after mRNA vaccination to recognize and neutralize SARS-CoV-2 variants. One of the main coordinators of this study is Professor Matthieu Mahévas of the […]
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