April 25 2022

Congratulations to Maëlle BRIOTTET, doctoral student in Sophie Lanone’s team in Valérie Urbach’s group, who received the Prize of the association Vaincre la Mucoviscidose during the French Symposium for Young Researchers

The Young Researchers’ Symposium mobilizes the French “muco” community around research. The 23rd edition took place this year on February 15, in a mixed format with a “remote” audience and a majority of speakers present at the association’s headquarters.   Twenty young researchers (selected by an ad hoc committee from 42 applications received) presented their […]

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April 19 2022

Omicron variant: Vaccination reveals a strong but incomplete immune escape. A study signed by Matthieu Mahévas’ group within the France Pirenne team and published this month in Immunity

  The Omicron variant of SARS-CoV-2 can escape neutralization by vaccine-induced antibodies as well as by antibodies from convalescent plasma. Memory B cells (MBs) represent a protective bulwark against SARS-CoV-2 because they persist after infection and vaccination enhances their affinity. The ability of BMs, generated by mRNA vaccines, to recognize the Omicron variant remains unknown […]

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April 8 2022

A new treatment for post-transplant leukemia relapse! A study by José Cohen’s I-BIOT team published this month in the Journal for Immunotherapy of cancer

Leukemia is a group of several types of blood cancer that affect up to 10,000 people in France each year. One of the proposed treatments is the transplant of hematopoietic stem cells. These cells are produced by the bone marrow and are the source of the various blood cells. Despite the success of this therapeutic […]

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March 1 2022

The DIM One Health 2.0 project led by Inserm and Prof. Jean-Daniel Lelièvre, accredited by the Ile-de-France region

The COVID-19 pandemic is a reminder of the reality of so-called emerging infectious diseases. These diseases represent in a caricatural way the “One Health” concept of a single health shared by humans and animals in their environment. This concept, which has become obvious in recent years, is the subject of numerous national and international projects. […]

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February 21 2022

Artificial intelligence predicts immune and inflammatory genetic signatures directly from hepatocellular carcinoma histology. A study led by Prof. Julien Calderaro and published in Journal of Hepatology

Immune gene signatures reflecting the quality and quantity of the intra-tumor immune infiltration are known to predict sensitivity to immunotherapy, but their use in the clinical setting is however challenging, as they require access to molecular biology platforms for the extraction of nucleic acids and their processing/sequencing. They are also highly dependent on sample quality […]

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February 7 2022

The FRM labels Bijan Ghaleh’s team for its project “The heme as a danger molecule during myocardial infarction”.

The project led by Roberta Foresti, Roberto Motterlini, Sandrine Pons and Bijan Ghaleh, focuses on the release of Danger Associated Molecular Patten (DAMP) during myocardial infarction, in particular heme.   The main objective is to demonstrate the role of heme, as DAMP and as a signal for HO-1 activation to modulate inflammation, protect the myocardium […]

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January 31 2022

Publication in Nature Medicine of the long-term results of the HGB-205 gene therapy trial for beta-hemoglobinopathies, conducted at the Necker Hospital and for which the analyses of patients with sickle cell disease were carried out by the France Pirenne team (N. Hebert, L. Kiger, P. Bartolucci).

  In the HGB-205 phase I/II clinical trial, four patients with transfusion-dependent beta thalassemia and three patients with sickle cell disease, aged 13 to 21 years, were treated with lentiviral gene therapy. They were followed for a median of 4.5 years.   The patients with beta thalassemia all became “transfusion independent” within the first month […]

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January 24 2022

Publication in Lancet of the results of the SEPREVEN* study: randomized trial conducted in 12 neonatal intensive care units in France with the theme of patient safety.

Promoted by the CHIC of Créteil with the support of the CRC of the CHIC, the results of the SEPREVEN* study were published on January 21, 2022 in the journal The Lancet.   This study is the result of a collaborative effort: it was coordinated by Dr. Laurence Caeymaex, head of the neonatal intensive care […]

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January 5 2022

Publication in the Journal of the American College of Cardiology (IF 24.09) of a study on the identification of typical clinical profiles in patients with suspected cardiac amyloidosis

In a work led by two members of Sylvie Bastuji-Garin’s CEpiA team (Etienne Audureau and Thibaud Damy) as part of Louis Bonnefous‘ thesis, the authors used innovative machine learning and visualization approaches to identify typical clinical profiles in a large population of suspected cardiac amyloidosis patients.   Clustering analysis identified 7 clinical profiles with varying […]

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December 18 2021

Publication of an article and editorial in the journal JACC on the beneficial effect of Ryanodine receptor stabilization to improve left ventricular function in young dogs with Duchenne muscular dystrophy

Duchenne muscular dystrophy is associated with progressive deterioration of left ventricular function. The golden retriever canine model of muscular dystrophy (GRMD) recapitulates the pathology and clinical manifestations of Duchenne muscular dystrophy. It is important to note that they develop progressive left ventricular dysfunction at an early age.   In an article (with an editorial) published […]

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December 13 2021

Publication of a study in Clinical Cancer Research on the identification of two main immune subtypes of cHCC-CCA (“Immune High” and “Immune Low”) in patients with mixed hepatocholangiocarcinoma tumors

Mixed hepatocholangiocarcinoma (cHCC-CCA) tumors are rare primary liver cancers associated with a very poor prognosis. They are resistant to all conventional cancer therapies and are characterized by the presence of a dual phenotype of both hepatocyte and biliary tumors. In a study conducted by Cong Trung Nguyen, Stefano Caruso and Pascale Maillé under the supervision […]

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December 7 2021

Congratulations to Marion LEBOYER who wins the Inserm Grand Prix 2021!

The Grand Prize recognizes the innovative nature of his work, particularly on bipolar disorders, schizophrenia and autism spectrum disorders. Just forty years ago, Marion Leboyer encountered psychiatry “by chance,” she admits. When choosing internship positions, I didn’t get the one for neuro-pediatric resuscitation, and I took what seemed to me to be the furthest from […]

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November 26 2021

Congratulations to Yannis Djeffal, PhD student in Frédéric Relaix’s team who receives the Line Pomaret-Delalande 2021 Prize (FRM Prize) for his thesis work on the understanding of the biology of muscle satellite cells

This prize, worth €105,600, comes from a donation by Sylvie Pomaret. Created in memory of his mother, it is intended to support research on rare diseases and finances a 3-year doctoral contract. Yannis Djeffal is pursuing a double degree in Medicine and Science. He is doing his doctoral work in science under the joint supervision […]

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October 1 2021

Congratulations to Pauline Favre, newly recruited as a research fellow at Inserm in Marion Leboyer’s team!

Pauline Favre is a neuropsychologist, recently recruited at INSERM as a CRCN researcher in Marion Leboyer’s team “Neuropsychiatrie Translationnelle”.   She did her PhD in Psychology, Cognitive Sciences and Neurocognition at the University of Grenoble (LPNC – CNRS) on the brain correlates of bipolar disorder and the contribution of psychoeducation in the treatment of this […]

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September 28 2021

Covid-19: a study of the effectiveness of immune memory after mRNA vaccination to recognize SARS-CoV2 variants

Teams from Henri-Mondor Hospital AP-HP and Université Paris-Est Créteil, Inserm, CNRS, Université de Paris, Institut Necker-Enfants malades, and Institut Pasteur have conducted research on the ability of the immune memory generated after mRNA vaccination to recognize and neutralize SARS-CoV-2 variants.   One of the main coordinators of this study is Professor Matthieu Mahévas of the […]

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