Under the chairmanship of Sir Malcolm Grant (recently President of the NHS England) and on the proposal of an international jury, the Prime Minister has selected 24 winners of the second wave of calls for projects “University Schools of Research“. Among them, EUR LIVE aims to address the problem of vulnerability by […]
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M. Panel, D. MOrin, B. Ghaleh (équipe 3), I. Ruiz, H. Ahmed-Belkacem, J-M. Pawlotsky Hepatic ischemia is a complication of liver surgery that involves mitochondrial dysfunction resulting from the opening of mitochondrial permeability transition pores (mPTP). Cyclophiline D (PPIF or CypD) is a peptidyl-prolyl cis-trans isomerase that regulates the mPTP opening in the […]
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Frédérique Vidal, Minister of Higher Education, Research and Innovation, Emmanuelle Wargon, Secretary of State to the Minister of State, Minister of Ecological and Solidarity Transition, Agnès Pannier-Runacher, Secretary of State to the Minister of the Economy and Finance and Guillaume Boudy, Secretary General for Investment, distinguished 140 winners of the i-Lab and i-Nov Innovation Competitions, […]
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Cindy Orvain, team 16 of the IMRB, has recently obtained her thesis with success. It is on the cover of the internal magazine Inserm In Vivo* in June 2019. She recounts her journey as part of the 16 team she joined in 2015, where she studies the regulation of effective responses of T cells and […]
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Autonomic nerve fibres in the tumour microenvironment regulate cancer initiation and dissemination, but how nerves emerge in tumours is currently unknown. Here we show that neural progenitors from the central nervous system that express doublecortin (DCX+) infiltrate prostate tumours and metastases, in which they initiate neurogenesis. In mouse models of prostate cancer, oscillations of […]
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A recent study conducted by Audrey Der Vartanian (post-doctoral researcher) and Marianne Gervais-Taurel (CNRS researcher) in the team of Pr. Frédéric Relaix (Team 10, IMRB) reveals that the transcription factor PAX3 protects a subpopulation of adult skeletal muscle stem cells in response to chronic exposure to an environmental pollutant, dioxin, with harmful effects on health. […]
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Professor Vincent Audard (Nephrology and Transplantation Department, IMRB Team 21) as coordinator of the Rare Disease Reference Centre (CRMR) “Idiopathic Nephrotic Syndrome” was presented on Tuesday 12 March 2019 during the Kidney Foundation gala (http://www.fondation-du-rein.org/) a research grant to set up within the 5 CRMR sites (Henri Mondor coordinator site, Robert Débré, Necker, Tenon and […]
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Stéphane Palfi, head of Team 14 at our Institute, will be René Frydman’s guest on France Culture’s “Matières à penser” program, dedicated this week to high hopes in medicine and new ideas. He will talk about the promises of stimulating the spinal cord to make paralytics walk again, but also about possible difficulties of experimentation […]
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It is around a cake of kings and surrounded by a large number of members of the IMRB, Mrs Camille Chaudonneret our regional delegate of Inserm Paris 6, as well as some members of the Faculty of Medicine, that our director Jorge Boczkowski presented us his wishes and encouragement for this year 2019 which […]
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A recent study conducted by Laura Braud, post-doctoral fellow in the Equipe directed by Roberto Motterlini (Equipe 12, IMRB), reveals that carbon monoxide (CO) improves insulin resistance and glucose metabolism in obese mice. The study appeared in the November issue of JCI Insight (Link: https://insight.jci.org/articles/view/123485). Braud and colleagues showed that oral administration of a compound […]
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EHVA (European HIV Vaccine Alliance) announces the start of the EHVA T01 / ANRS VRI05 trial. EHVA-T01 / ANRS VRI05, a double-blind, randomized, Phase I/II trial, will evaluate the combination of experimental HIV therapeutic vaccines and an investigational immunotherapy drug in people living with HIV in six European countries – France, Germany, Spain, Italy, […]
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Claire Leibler, a nephrologist specializing in kidney transplantation, received the thesis prize from the University of Paris Est for the Doctoral School of Life and Health Sciences (SVS) on November 6. On December 2, she will also receive the Aguirre-Basulado / Robin Prize for Medicine, one of the fifty solemn prizes awarded by the Chancellery […]
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The majority of adult stem cells are sustained quiescent throughout the lifetime of an organism. A central quest in the stem cell field is to identity the signals that maintain quiescence. Characterization of those signals and their modes of interaction is a major challenge but also a prerequisite for the use of stem cells in […]
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According to a recent study coordinated by Pablo Bartolucci of Team 2, with the help of the Department of Public Health and Cardiorespiratory Rehabilitation of CHU Henri Mondor and published in the journal Lancet Haemtology in November 2018, physical exercise would bring definite benefits in the treatment of sickle cell disease. The article appeared in […]
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Duchenne muscular dystrophy (DMD) is a progressive neuromuscular disease, affecting 1 in 5000 live male births and is characterized by a progressive degeneration of myofibres, leading to an irreversible muscle weakness. In DMD, as in many muscle wasting conditions, cell death mechanisms are largely unknown. Within the team 10 directed by Frederic Relaix and Jérôme […]
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Marion Leboyer, director of team 15 of the IMRB, the FondaMental Foundation, and head of department at the Chenevier-Mondor hospital in Créteil, has just given an interview as part of the “Entretiens de Médecine/Sciences” conducted jointly by the scientific journal and INSERM. During this interview she talks mainly about the immune system in psychiatry, but […]
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