In partnership with INSERM and CNRS, “EUR-LIVE” is a project designed within the framework of the “Investissements d’Avenir” (PIA) projects and supported by the ANR. EUR-LIVE (ANR-18-EUR-0011) aims to combine the know-how and research contributions of multiple disciplines to address vulnerability in all its facets, by creating a University Research School at UPEC. See […]Read more
Interview with Prof. Marion Leboyer (IMRB-U955, Leboyer team) for the Institut Montaigne*: The mental health of young French people is deteriorating according to an IPSOS survey conducted for the FondaMental Foundation**.
Conducted in December 2020, the IPSOS survey reveals that since the beginning of the health crisis, young people, women and the most precarious are suffering the full impact of this crisis, whose figures speak for themselves: – 31% of the population has a suspicion of generalized anxiety disorder. Among 22-24 year olds, the figures rise […]Read more
“Acting together for a fairer and more enlightened society” is the vision of the new UPEC Foundation, created by the university and four co-founders (BNP Paribas, Thales, the Seine-et-Marne Departmental Council and Agefiph). The foundation aims to provide new resources and support the ambitions of the university, which is committed to the promotion of excellence […]Read more
Rituximab-resistant memory B cells contribute to relapse in adult patients with immunological thrombocytopenia: A study led by Professor Matthieu Mahevas, Pirenne team at IMRB and published in Science Translational Medicine
Teams led by Prof. Matthieu Mahévas of the Reference Center for Autoimmune Cytopenias in Adults and the Mondor Institute of Biomedical Research (Henri-Mondor Hospital AP-HP/Inserm/University of Paris-Est Créteil), Prof. Jean-Claude Weill and Dr. Claude-Agnès Reynaud at the Institut Necker-Enfants Malades (Inserm/CNRS/University of Paris) studied the presence of self-reactive memory B lymphocytes before and after rituximab […]Read more
COVID-19: Discovery of a new variant at the Henri-Mondor Hospital by the teams of the virology laboratory, the “Genomics” platform, and the IMRB
Teams from the virology laboratory (Dr Slim FOURATI) and the “Genomics” platform (Dr Christophe RODRIGUEZ) of the Henri-Mondor Hospital AP-HP, Inserm and the University Paris-Est Créteil (Institut Mondor de Recherche Biomédicale, U955 Inserm-Université Paris-Est Créteil), under the direction of Professor Jean-Michel PAWLOTSKY, have discovered a new variant of SARS-CoV-2, the virus responsible for COVID-19. […]Read more
Congratulations to Mathieu Panel (ex-doctoral fellow of the Ghaleh team) honored in the Journal of Pharmacology and Experimental Therapeutics of March 2021!
After receiving the Prix des Sciences du Médicament by the French National Academy of Pharmacy in February 2020, Mathieu Panel, a former IMRB doctoral student in Bijan Ghaleh’s team, has just been highlighted as a trainee author in the Journal of Pharmacology and Experimental Therapeutics in the March 2021 issue. The paper for which […]Read more
A study on the nature and significance of the early cellular responses as they occur in vivo after tissue injury, is published in Cell Stem Cell from the Team-Relaix
In multicellular organisms, cells dynamically interact with the microenvironment, which determines their properties and gene-expression profile. Tissue damage, such as injury or experimental cell dissociation, leads to dramatic modifications of the niche, yet the early cellular responses in vivo remain ill-defined. Focusing on two highly regenerative organs, the skeletal muscle and the liver, we identified […]Read more
Innovative HIV vaccine trial: The Vaccine Research Institute is looking for volunteers living in the Ile de France region
The Vaccine Research Institute (VRI, ANRS-Inserm and Université Paris-Est Créteil) is seeking 72 volunteers between the ages of 18 and 65, living in the Ile-de-France region, with no health problems to participate in a phase I trial of a preventive HIV vaccine. In partnership with Sida Info Service, this recruitment has a dedicated website, […]Read more
Congratulations to Isaac Ruiz, Jean-Michel Pawlotsky’s team, winner of the Special Jury Prize (University Prize 2020) for his doctoral thesis in Hepatology and Virology
Each year, the Val-de-Marne Department supports research by rewarding the best academic work through the University Prize. Isaac Ruiz received the Special Jury Prize for his doctoral thesis from the University of Paris-Est Créteil in Hepatology and Virology: Development of new therapeutic approaches in Virology and Hepatology: Small-Molecule Cyclophilin Inhibitors (SMCypI). Isaac Ruiz […]Read more
Congratulations to Philippos Mourikis, Frédéric Relaix’s team! His Calci-Notch project in the framework of the International Call for Research Projects (PRI) 2020, has been selected by Inserm among more than 70 projects submitted
Launched in June 2020, the International Research Project (PRI) call was a great success with more than 70 projects submitted for this first edition. Only 15 projects have been selected, and that of Philippos Mourikis, DR in Fred Relaix’s team, in collaboration with Dr. Fukada’s team from the University of Osaka in Japan, is […]Read more
Publication in Cell of a study led by Matthieu Mahevas of the Pirenne team, in collaboration with several IMRB teams, on the maturation and persistence of the anti-SARS-CoV-2 and COVID-19 immune response.
B memory cells play a fundamental role in the host’s defenses against viruses, but so far their role has been relatively undefined in the context of CoV-2 SARS. Matthieu Mahévas and several members of the Pirenne team, associated with several teams at the Institute (Bastuji-Garin, Cohen, Lévy and Pawlotsky teams), the Necker Institute for […]Read more
Interview with Marcel Filoche, Bruno Louis’ team in the France Culture program “La méthode scientifique” on the benefits of Surfactant Substitution Therapy in patients with severe COVID-19 and who develop an Acute Respiratory Distress Syndrome (ARDS)
In the deepest parts of the pulmonary air shaft, gas exchange between air and blood takes place within about 500 million alveoli (small spherical chambers about 1/4 mm in diameter). The surface of these alveoli, whose developed surface is of the order of 100 m^2 in the adult, is lined with a liquid layer itself […]Read more
IMRB’s Relaix team publishes in the journal Cell Metabolism the discovery of a mitochondrial transfer mechanism from platelets activating the repair function of mesenchymal stem cells
Platelets are commonly used in clinical applications. In particular, they are known to stimulate the repair properties of mesenchymal stem cells, these effects being usually attributed to the many growth factors that they release following their activation. The study headed by Anne-Marie Rodriguez with Jennyfer Levoux, Alexandre Prola and Peggy Lafuste as first co-authors […]Read more
A mechanism controlling the efficiency of mitochondrial coupling has been revealed: mechanistic and medical perspectives
In an article available here, published on January 1st in Science Advances, the comparative medical genetics group of the BNMS team reveals an original mechanism by which the content of cardiolipin, a phospholipid present in the inner membrane of mitochondria, controls the coupling efficiency between the oxidation of energy substrates and the phosphorylation of ADP […]Read more
Main issues and limitations of the contribution of Artificial Intelligence (AI) for the management of patients with gastrointestinal and hepatic cancers
Artificial Intelligence (AI) can extract complex information from visual data. Histopathological images of cancers indeed contain a very large amount of information that human observers can only partially understand. Thus, AI allows a thorough analysis of digitized histological slides and offers a wide range of clinically relevant applications, such as the identification of prognostically […]Read more
Congratulations to Ophélia Godin, newly recruited as a researcher at Inserm as part of Marion Leboyer’s team!
Ophélia Godin is an epidemiologist by training, recently recruited at INSERM as a CRCN researcher at the Mondor Institute for Biomedical Research in Marion Leboyer’s team “Translational Psychiatry”. She did her thesis in Public Health at the University of Paris 11 on the cerebral modifications visible on MRI of dementia in the elderly and has […]Read more