bandeau_equipe1

Interventional neuropsychology

The team Interventional Neuropsychology (NPI) is a research unit affiliated to INSERM, UPEC, and Ecole Normale Supérieure of Paris and is headed by Prof. Anne-Catherine Bachoud-Lévi.
NPI is geographically settled in two sites:
– The Mondor Biomedical Research Institute (IMRB) located in the Faculty of Medicine of UPEC at Créteil
– the Institute for Cognitive studies (IEC) at Ecole Normale Supérieure in Paris.

 

Research topics :

 

Two major themes are investigated in our laboratory. The first one is the study of human communication and the cognitive processes involved in language and social cognition. The second one is a transverse research using innovative therapies like cells grafts, to restore cerebral tissues in the process of degeneration.
The originality of the team lies in the combination of clinical research on the development of new therapeutic approaches and basic research in cognition. This allows to study cognition and its degeneration in degenerative diseases as well as its restoration and the associated brain plasticity in patients enrolled in therapy program. This also allows to intervene for improving treatment and the care of patients with degenerative diseases, notably Huntington’s disease.

 

NPI activity relies on the national reference centre for Huntington disease (AP-HP ; Henri Mondor Hospital ; Creteil)
The NPI approach is threefold:
1) Experimentations on healthy adults in order to develop new language and social cognition models.
2) Study of language and social cognition in brain-lesioned adults (stroke or neurodegenerative diseases such as Huntington disease and Parkinson disease).
3) Innovative therapies application (intracerebral grafts, gene therapies) to restore cognitive functions and understand functional recovery processes.

 

Keywords :

 

Language ; Psycholinguistics ; Linguistics ; Social cognition ; neurodegenerative disease ; Hintington ; Parkinson ; Intracerebral grafts ; Striatum ; fMRI ; EEG

 

External collaborations :

 

NPI is linking biological skills (research in bio-markers; imaging, genetics) and behavioural research (experimental psychology, ERP, PET scan, fMRI, VBM) thanks to collaboration with CEA and IHU-A-ICM.

http://icm-institute.org/fr/
http://i2bm.cea.fr/dsv/i2bm/Pages/MIRCen.aspx

Selected publications

Sun Y, Giavazzi M, Adda-Decker M, Barbosa LS, Kouider S, Bachoud-Lévi AC, Jacquemot* C, Peperkamp* S. Complex linguistic rules modulate early auditory brain responses

Brain Lang. 2015 Jul 14;149:55-65

Teichmann M, Rosso C, Martini JB, Bloch I, Brugières P, Duffau H, Lehéricy S, Bachoud-Lévi AC. A cortical-subcortical syntax pathway linking Broca's area and the striatum

Hum Brain Mapp. 2015 Jun;36(6):2270-83.

Cleret de Langavant L, Sudraud S, Verny C, Krystkowiak P, Simonin C, Damier P, Demonet JF, Supiot F, Rialland A, Schmitz D, Maison P, Youssov K, Bachoud-Lévi AC. Longitudinal study of informed consent in innovative therapy research: experience and provisional recommendations from a multicenter trial of intracerebral grafting

PLoS One. 2015 May 26;10(5):e0128209

López-Barroso D, Ripollés P, Marco-Pallarés J, Mohammadi B, Münte TF, Bachoud-Lévi AC, Rodriguez-Fornells A, de Diego-Balaguer R. Multiple brain networks underpinning word learning from fluent speech revealed by independent component analysis

Neuroimage. 2015 Apr 15;110:182-93.

Callaghan J, Stopford C, Arran N, Boisse MF, Coleman A, Santos RD, Dumas EM, Hart EP, Justo D, Owen G, Read J, Say MJ, Durr A, Leavitt BR, Roos RA, Tabrizi SJ, Bachoud-Levi AC, Bourdet C, van Duijn E, Craufurd D. Reliability and factor structure of the Short Problem Behaviors Assessment for Huntington's disease (PBA-s) in the TRACK-HD and REGISTRY studies

J Neuropsychiatry Clin Neurosci. 2015 Winter;27(1):59-64.

Palfi S, Gurruchaga JM, Ralph GS, Lepetit H, Lavisse S, Buttery PC, Watts C, Miskin J, Kelleher M, Deeley S, Iwamuro H, Lefaucheur JP, Thiriez C, Fenelon G, Lucas C, Brugières P, Gabriel I, Abhay K, Drouot X, Tani N, Kas A, Ghaleh B, Le Corvoisier P, Dolphin P, Breen DP, Mason S, Guzman NV, Mazarakis ND, Radcliffe PA, Harrop R, Kingsman SM, Rascol O, Naylor S, Barker RA, Hantraye P, Remy P, Cesaro P, Mitrophanous KA. Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial.

Lancet. 2014 Mar 29;383(9923):1138-46.

Bartolomeo P, Bachoud-Lévi AC, Thiebaut de Schotten M. The anatomy of cerebral achromatopsia: a reappraisal and comparison of two case reports

Cortex. 2014 Jul;56:138-44

Cleret de Langavant L, Fénelon G, Benisty S, Boissé MF, Jacquemot C, Bachoud-Lévi AC. Awareness of memory deficits in early stage Huntington's disease

PLoS One. 2013 Apr 19;8(4):e61676.

 

Significant publications (2009-2015)