Virginie Firlej (team 7), co-author with the CEA of Fontenay-aux_Roses, of a publication in the journal Nature of May 15 on neural progenitors of the central nervous system expressing double-cortin (DCX+), infiltrate prostate tumors and metastases, and initiate neurogenesis.
Autonomic nerve fibres in the tumour microenvironment regulate cancer initiation and dissemination, but how nerves emerge in tumours is currently unknown. Here we show that neural progenitors from the central nervous system that express doublecortin (DCX+) infiltrate prostate tumours and metastases, in which they initiate neurogenesis. In mouse models of prostate cancer, oscillations of DCX+ neural progenitors in the subventricular zone—a neurogenic area of the central nervous system—are associated with disruption of the blood–brain barrier, and with the egress of DCX+ cells into the circulation. These cells then infiltrate and reside in the tumour, and can generate new adrenergic neurons. Selective genetic depletion of DCX+ cells inhibits the early phases of tumour development in our mouse models of prostate cancer, whereas transplantation of DCX+ neural progenitors promotes tumour growth and metastasis. In humans, the density of DCX+ neural progenitors is strongly associated with the aggressiveness and recurrence of prostate adenocarcinoma. These results reveal a unique crosstalk between the central nervous system and prostate tumours, and indicate neural targets for the treatment of cancer.
This work is the result of close collaboration with the CEA team at Fontenay aux Roses by Claire Magnon.
Schwann cells « metamorphosis » in Neurofibromatosis type 1 :
«Piotr Topilko - 12h – Amphi 5, 4ème étage de la Faculté de Santé de Créteil»
Soutenance de thèse : Dysfonctions lymphocytaires et extinction de CMIP lors du syndrome néphrotique idiopathique à lésions glomérulaires minimes :
«Julie Oniszczuk - 13h30 – Salle Alain Harf, Rdc de la Faculté de Santé de Créteil»
Séminaire technique : SIMOA SR-X : Technologie ultrasensible de détection de biomarqueurs protéiques :
«Milena Dumont Milutinovic - 14h – Salle 3058, 3ème étage de la Faculté de Santé de Créteil»
All incoming seminars
A research and medical care network for psychiatryRead more
Vaccine research institute
An institute to foster the design of vaccines against HIV and hepatitis CRead more