Cardiovascular and respiratory diseases are becoming increasingly prevalent in most countries, generating major disability and cost burdens for society. Strong and tightly coordinated research efforts are needed to advance the comprehension of these diseases with the goal of improving and developing therapies. These efforts must include translational research strategies, as well as basic research on underlying cellular and molecular mechanisms, including evaluations of cellular senescence, cellular mechanics and genetics, developmental processes, and morphogenesis.
PHYDES is a translational research department structuring research dedicated to pathoPHYsiology of cardiovascular and respiratory diseases, DEvelopment and Senescence. It covers the activities performed in the hospital and university department, A-TVB (Ageing, Thorax, Vessels, Blood) of the Henri Mondor Hospital and UPEC (Université Paris-Est Créteil), from ageing to the genetic and biomechanical aspects of cardiovascular and respiratory diseases, red-blood-cell and some congenital diseases.
PHYDES is composed of eight teams whose research is dedicated to the investigation of the molecular mechanisms relevant to the pathophysiology of major diseases.
The goal of the PHYDES department is to develop:
– Basic and translational projects related to major aspects of cardio-thoracic medicine such as myocardial ischemia and heart failure, systemic and pulmonary vascular diseases (including consequences of genetic red-blood-cell diseases, and pulmonary hypertension), acute and chronic respiratory failure (including smoking- and occupation-related COPD), genetic respiratory diseases (cystic fibrosis and ciliopathies), and physiological and pathological aspects of neural crest development
-Training in cardio-thoracic research of students having both medical and scientific backgrounds, in particular at the doctoral level
– Technology transfer in the fields of cardio-thoracic medicine.
PHYDES is promoting scientific animation and interactions between teams which develop complementary approaches and research to study the molecular and cellular mechanisms shared by these diseases such as cell senescence, inflammation, and biomechanics, as well as the molecular and cellular bases of chosen human genetic disorders with the aim of developing high various innovative therapeutic strategies as well as new and personalised treatments and to attract new teams to reinforce the basic and translational research on the diseases of interest.
Pharmacological strategies and experimental therapeutics for myocardial ischemia and heart failure
Physiopathology of COPD and other respiratory consequences of environmental particle inhalation
We work for several years with Pr. Jim Grotberg the University of Michigan (Biomedical Engineering Department) on various aspects of transport in the lung airways. The surfactant replacement therapy is a technique that involves administering intratracheally by the surfactant that lines the deep areas of the lungs and allows it to change the volume evenly […]Read more
Team 10 of Frédéric Relaix and François-Jérôme Authier associated with several German and French teams, published a very interesting article in the journal Nature Communications on October 31st, 2017. A story that identifies the embryonic origin of FAPs (Fibro-Adipogenic Progenitors), the population of adult muscle mesenchymal stem cells that differentiate into adipocyte and give fibrosis in pathological expectations...Read more